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In the meta-analysis, GLP-1 receptor agonists reported a significant reduction in MACE compared with placebo (HR (95%CI): 0.86 (0.810.92)

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In Phase 2 trials, retatrutide was administered as a once-weekly subcutaneous injection with a structured dose-escalation protocol

miRNA-mediated and epigenetic regulatory mechanisms GLP-1RAs participate in the epigenetic regulation of the processes of tumorigenesis and cancer progression by modulating gene expression and changes in DNA methylation